Названия:
ARTIFICIAL BLOOD: THE FRONTIER OF TRANSFUSION MEDICINE AND HEMOGLOBIN-BASED OXYGEN CARRIERS
Автор:
Gulmuhammedova Selbi, Hommekova Ogulnar
Расположение страниц:
148-153
Язык:
Английский
Аннотация:
This article presents a comprehensive and maximally detailed examination of the field of Artificial Blood research, focusing specifically on the primary class of clinical-grade substitutes known as Oxygen Carriers. These innovative solutions are designed to address the persistent global shortage of donated human blood and eliminate the associated risks of disease transmission and immunological incompatibilities. The necessity for a safe, universally compatible, and storable blood substitute is paramount in trauma care, emergency medicine, and military combat casualty management. The analysis meticulously differentiates between the two leading categories of blood substitutes: Hemoglobin-Based Oxygen Carriers (HBOCs) and Perfluorocarbon-Based Oxygen Carriers (PFOCs). The article thoroughly explores the complex biochemical challenges associated with stabilizing and encapsulating oxygen-carrying molecules, the critical pharmacokinetic and safety issues (particularly vasoconstriction and toxicity), and the profound potential of these substitutes to revolutionize transfusion logistics and global emergency response protocols. The development of artificial blood represents one of the most significant and challenging ongoing projects in both materials science and biomedical engineering.